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The U.S. Food and Drug Administration has approved the use of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help manage chronic obesity in older adults with a body mass index (BMI) of greater than 27, so long as they also are afflicted by weight-related health issues such as Tupe2 diabestes, high cholesterol and/or hypertension (high blood pressure).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in the extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder so when an aid to stopping smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director in the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle including a reduced-calorie dieting and exercise, Contrave provides another treatment selection for chronic weight management for people who are obese or are overweight and also have at least one weight-related health problem.'The drug's effectiveness was evaluated in multiple many studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for starters year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular exercise. Results from a clinical trial that enrolled patients without diabetes established that patients had an average weight loss of 4.1% as opposed to participants who have been given placebos) within a 12- month period, while a separate study involving patients with diabetes type 2 symptoms had a typical weight loss of 2% over treatment with placebo at 12 months.

Using two separate drugs to shed pounds can be very effective you can find combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the those who go through it you should err to the side of caution and allow the FDA do its job and demand some study be done so that the public knows the side effects and hazards of the medications before we bring them. Keep in mind that drug companies are in business to generate money and that they would say almost anything to keep people on their medications.

Researchers discovered that participants using this drug to get a year, lost weight within four weeks and have kept the extra weight off throughout the 56 weeks from the study. Contrave is often a combination in the drugs naltrexone and bupropion, which generally seems to reflect a whole new trend of weight-loss drugs which might be made up of more than one active ingredient, that might make them more effective and safer.

Combo-pilling could be the newest fad or better yet the newest ahead under scrutiny and thus it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular could be the fact that by right now there are not any long term prescription weight loss supplements that have been approved by the FDA aside from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations happen to be rejected or have yet to be approved by the FDA.

Seizures can be a side effect with Contrave and mustn't be taken in people with seizure disorders. The drug can also raise blood pressure levels and pulse rate, and must not be used in individuals with a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise hypertension and pulse rate and must stop used in patients with uncontrolled high blood pressure levels, as well as by anyone with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients using a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave must have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes with a boxed warning to alert physicians and patients towards the increased risk of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

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